TOXICOGENOMIC TECHNOLOGIES AND RISK ASSESSMENT OF ENVIRONMENTAL CARCINOGENS: A Workshop Summary by National Research Council of the National Academies

Author:National Research Council of the National Academies
Language: eng
Format: epub
Tags: Environment and Environmental Studies : Environmental Health and Safety. Health and Medicine : Environmental Health
Publisher: NATIONAL ACADEMY PRESS
Published: 2005-10-17T00:00:00+00:00

Preneoplastic Changes

In conventional toxicity studies, empirical evidence of tumors or other morphologic evidence of chronic toxicity often takes months or years to appear. However, genomic techniques may allow for the identification of characteristic preneoplastic gene-expression profiles that can be detected within hours or days of exposure and foretell disease.

FIGURE 3 Gene network diagram derived from DNA microarray experiments using circuitry analysis, a bioinformatics approach using the Osprey network visualization system (Breitkreutz et al. 2003). These data come from experiments in which Ramos and colleagues sought to identify associations between the expression patterns of individual genes regulated by ligands of the aryl hydrocarbon receptor (Ahr). Several target genes affected by the Ahr ligands were examined: Ahr, cytochrome P450 1B1 (Cyp1b1), insulin-like growth factor-binding protein-5 (IGFbp5), lysyl oxidase (LOX), and osteopontin (OPN). The genes listed on the outside of the figure were identified as the best predictors of the five target genes in the center of the figure. The lines denote predictive connection among the genes in the network. The weight of each line conveys the strength of the prediction (for example, the correlation is stronger between IGFbp-6 and Cyp1b1 than between IGFbp-6 and Ahr). Source: Johnson et al. 2004.

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